Table 3.
Univariate and multivariate Cox regression analysis of TCIRG1 expression classifier and clinical characteristics with Overall Survival and Progression Free Survival in validation cohort (n = 263)
| Characteristics | Overall survival | Progression Free Interval | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Univariate | Multivariate | Univariate | Multivariate | ||||||||||||
| HR (95%CI) | p Value | HR (95%CI) | p Value | HR (95%CI) | p Value | HR(95%CI) | p Value | ||||||||
|
Age (≥ 60 vs. < 60) |
1.729 (1.123–2.663) | 0.013 | 1.398(0.898–2.178) | 0.138 | 1.379(0.892–2.132) | 0.149 | |||||||||
|
Gender (Male vs. Female) |
0.817(0.537–1.242) | 0.344 | 1.265(0.798–2.006) | 0.317 | |||||||||||
|
TNM stage (III-IV vs. I-II) |
4.760(3.028–7.481) | < 0.001 | 3.509(2.159–5.701) | < 0.001 | 7.036(4.274–11.581) | < 0.001 | 5.868(3.476–9.907) | < 0.001 | |||||||
|
Pathological grade (III-IV vs. I-II) |
2.467(1.554–3.915) | < 0.001 | 1.432(0.878–2.335) | 0.150 | 3.061(1.864–5.026) | < 0.001 | 1.994(1.171–3.394) | 0.011 | |||||||
|
TCIRG1 expression (High vs. Low) |
2.373(1.566–3.596) | < 0.001 | 1.679(1.086–2.596) | 0.020 | 1.658(1.075–2.559) | 0.022 | 0.897(0.568–1.419) | 0.643 | |||||||
* TCIRG1 was divided into high and low expression groups with an optimal cutoff value of 3.82
TCIRG1 low expression: Gene expression level of TCIRG1 < 3.82;
TCIRG1 high expression: Gene expression level of TCIRG1 ≥ 3.82;
Statistical significance was calculated by Chi squared test or Fisher’s exact test for categorical/binary measures
Abbreviation: ccRCC, clear cell renal cell carcinoma