Table 1.
Participant characteristics
| Characteristics | N = 948 | Maternal sample | Inception cohort | |
|---|---|---|---|---|
| Mean (SD), Median [IQR] or % (n) | N = 1074 | Mean (SD), Median [IQR] or % (n) | ||
| Parent and Household factors | ||||
| Mother's age at conception (years) | 948 | 31.5 (4.7), 31.8 [28–34] | 1074 | 31.3 (4.8), 31.7 [28–35] |
| Father's age at conception (years) | 907 | 33.6 (5.7), 33.4 [30–37] | 1024 | 33.5 (5.9), 33.3 [30–37] |
| Mother is university-educated | 945 | 52.6% (497) | 1068 | 51.3% (548) |
| Father is university-educated | 929 | 36.2% (336) | 1044 | 35.2% (367) |
| Socioeconomic index (lowest tertile) | 937 | 32.2% (302) | 1061 | 33.6% (357) |
| All grandparents are of European descent | 940 | 74.6% (701) | 1060 | 73.0% (774) |
| Child's sex | 948 | 1074 | ||
| Female | 48.3% (458) | 48.3% (519) | ||
| Prenatal factors | ||||
| Pre-pregnancy BMI (kg/m2) | 824 | 25.4 (5.4), 24.0 [22–28] | 927 | 25.4 (5.5), 24.0 [22–28] |
| Maternal weight—28-week interview (kg) | 764 | 80.9 (15.4), 78.1 [70–88] | 866 | 80.9 (15.5), 78.1 [70–89] |
| Gestational age—blood collection (wks) | 948 | 28.2 (1.2), 28.0 [28, 29] | 1047 | 28.3 (1.3), 28.1 [28, 29] |
| Edinburgh Depression Scale risk category | 682 | 766 | ||
| Low risk < 10 | 83.6% (570) | 82.9% (635) | ||
| Moderate risk 10–12 | 10.9% (74) | 11.0% (84) | ||
| High risk > 12 | 5.6% (38) | 6.1% (47) | ||
| Any ETS during preconception or pregnancy | 927 | 15.6% (145) | 1049 | 16.9% (177) |
| Maternal smoking throughout pregnancy | 940 | 5.2% (49) | 1061 | 6.3% (67) |
| Gestational diabetes mellitus | 812 | 4.9% (40) | 908 | 4.8% (44) |
| Pre-eclampsia | 915 | 3.0% (27) | 1039 | 3.4% (35) |
| Any alcohol consumption during pregnancy | 894 | 52.5% (469) | 989 | 52.7% (521) |
| Vegetarian diet | 944 | 0.6% (6) | 1016 | 0.6% (6) |
| Folate supplementation during pregnancy | 917 | 97.3% (892) | 1030 | 97.4% (1,003) |
| Omega-3 supplementation in pregnancy | 589 | 57.4% (338) | 637 | 57.9% (369) |
| Omega-6 supplementation during pregnancy | 919 | 0.2% (2) | 1034 | 0.2% (2) |
| Fish oil supplementation during pregnancy | 562 | 16.4% (92) | 608 | 16.1% (98) |
BMI body mass index; ETS environmental tobacco smoke; T1 & T2 trimester 1&2