Table 1.
Intestinal bacteria significantly causally associated with severe COVID-19.
| Taxon | Method | nSNP | OR (95%CI) | pmr | Q value | ppleio | Level |
|---|---|---|---|---|---|---|---|
| Alloprevotella | IVW | 4 | 1.627 (1.14-2.323) | 0.007 | 0.151 | 0.489 | e5 |
| Anaerotruncus | Wald ratio | 1 | 0.213 (0.076-0.595) | 0.003 | NA | NA | e6 |
| Bifidobacterium | IVW | 2 | 2.092 (1.149-3.808) | 0.016 | NA | NA | e7 |
| Bifidobacterium | Wald ratio | 1 | 2.376 (1.211-4.663) | 0.012 | NA | NA | e8 |
| Butyrivibrio | IVW | 14 | 0.83 (0.69-1.000) | 0.050 | 0.052 | 0.132 | e5 |
| Gordonibacter | Wald ratio | 1 | 0.578 (0.335-0.998) | 0.049 | NA | NA | e6 |
| Howardella | IVW | 7 | 1.264 (1.009-1.583) | 0.042 | 0.401 | 0.160 | e5 |
| Oxalobacter | IVW | 11 | 0.842 (0.709-1.000) | 0.050 | 0.543 | 0.590 | e5 |
| Oxalobacter | IVW | 4 | 0.752 (0.578-0.98) | 0.035 | 0.722 | 0.377 | e6 |
| Rikenellaceae RC9 gutgroup | Wald ratio | 1 | 0.627 (0.421-0.935) | 0.022 | NA | NA | e6 |
| Ruminiclostridium 6 | IVW | 14 | 0.708 (0.544-0.921) | 0.010 | 0.331 | 0.500 | e5 |
| Ruminococcus gnavus group | IVW | 2 | 1.703 (1.018-2.849) | 0.043 | 0.538 | NA | e6 |
| Ruminococcus torques group | Wald ratio | 1 | 6.66 (2.225-19.937) | 0.001 | NA | NA | e7, e8 |
| Tyzzerella3 | Wald ratio | 1 | 0.452 (0.255-0.802) | 0.007 | NA | NA | e8 |
| unknowngenus.id.1000001215 | IVW | 5 | 0.72 (0.536-0.966) | 0.029 | 0.346 | 0.336 | e5 |
Note: nSNP, number of selected IVs; OR, odds ratio; CI, confidence interval; pmr, MR analysis p value; Q value, Cochran test Q value; ppleio, pleiotropy test p value; Level, IVs screen p value level; e5, p<1×10-5; e6, p<1×10-6; e7, p<1×10-7; e8, p<1×10-8; NA, not applicable.