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. 2023 Aug 16;14:1203087. doi: 10.3389/fphar.2023.1203087

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Copyright © 2023 Lin, Soorneedi, Guan, Tang, Shi, Moore and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Heatmaps for expression of genes related to serotonin and Wnt pathways and Wnt/β-catenin signaling in Caco-2 cells cultured in conditioned media with and without ROS inhibitor NAC pre-treatment. (A) Gene expression heatmaps for the effect of NAC (100 μM) pre-treatment on expression of genes related to serotonin and Wnt pathways in conditioned medium-treated Caco-2 cells. (B) Wnt/β-catenin signaling, as indicated by TCF/LEF luciferase reporter gene activation, in response to NAC (100 μM) pre-treatment in conditioned medium-treated Caco-2 cells. ROS, Reactive Oxygen Species; NAC, ROS inhibitor N-acetyl-l-cysteine. Data was presented as mean ± SEM, n = 3. ***p < 0.001, as compared to the control. Abbreviation: w/, with; w/o, without.