TABLE 1.

Bioactive Component analyses among 4 groups of supernatants by HILIC method. CM, fresh bacterial culture medium; TCM, Turicibacter culture medium; ACCM, fresh medium with AC; TACCM, Turicibacter culture medium with AC. Data was presented as relative mean AUC ±SEM compared to CM, n = 3. Red color indicates the statistical significances between CM and TCM or ACCM and TACCM. ^# p < 0.1, *p < 0.05 indicate the differences between CM and ACCM or TCM and TACCM.

	CM	TCM	ACCM	TACCM
α-Ketoglutaric acid	1.000 ± 0.099	$\text{2.031 ± 0.207}$	10.014 ± 3.368 $*$	$\text{25.650 ± 1.978*}$
N-Acetyl-L-Glutamine	1.000 ± 0.111	0.838 ± 0.056	4.090 ± 0.466 $*$	5.045 ± 0.397 $*$
N-Acetyl-L-Glutamic acid	1.000 ± 0.142	0.984 ± 0.164	1.692 ± 0.290 #	2.470 ± 0.087 $*$
Dimethylglycine	1.000 ± 0.011	$\text{1.265 ± 0.064}$	1.817 ± 0.175 $*$	2.202 ± 0.025 $*$
Serotonin	1.000 ± 0.069	1.190 ± 0.080	1.927 ± 0.133 $*$	$\text{2.674 ± 0.165*}$
Choline	1.000 ± 0.005	$\text{1.226 ± 0.045}$	1.761 ± 0.133 $*$	2.023 ± 0.035 $*$
Acetylcholine	1.000 ± 0.182	1.039 ± 0.168	3.250 ± 0.086 $*$	3.533 ± 0.103 $*$
N-Acetyl-L-Aspartic acid	1.000 ± 0.027	$\text{1.556 ± 0.056}$	5.252 ± 0.036 $*$	5.602 ± 0.224 $*$
Citric acid/Isocitric acid	1.000 ± 0.078	1.029 ± 0.082	1.410 ± 0.029 $*$	1.479 ± 0.059 $*$
Oxalic acid	1.000 ± 0.150	$\text{1.616 ± 0.154}$	94.349 ± 0.036 $*$	114.887 ± 16.008 $*$
Lactic acid	1.000 ± 0.039	$\text{60.873 ± 0.623}$	1.475 ± 0.032 $*$	$\text{41.809 ± 1.159*}$
Butyric acid	1.000 ± 0.081	0.669 ± 0.192	32.533 ± 1.171 $*$	28.020 ± 2.694 $*$