Fig. 5.

PSMA1 locus. (A) Locus zoom around the 11:7117503 glucose association [Glucose −log₁₀(P) facet] near PSMA1. Top facet shows islet enhancers, called from islet H3K27ac ChIP-seq and ATAC-seq data. rs75336838 (blue) is one of three SNPs in the 95% glucose credible set (PPA facet), has a large IEP score (IEP facet), and occurs in an ESR region (green; EDR regions shown in orange), defined by ED scores from in silico saturated mutagenesis (ED score facet). Dashed box indicates the ESR containing the candidate SNP (blue line). (B) Electrophoretic mobility shift assay (EMSA) for all SNPs in the 95% credible set. (C) Competition EMSA for rs75336838. Red arrows indicate bands of interest. (D) Average luciferase activity across replicates for both alleles of candidate SNPs. Error bars correspond to SE. *** indicates Wilcoxon rank sum test P < 0.001.