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. 2023 Aug 16;14:1188392. doi: 10.3389/fimmu.2023.1188392

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Copyright © 2023 Dickson, Geerling, Stone, Hassert, Steffen, Makkena, Smither, Schwetye, Zhang, Georges, Roberts, Suschak, Pinto and Brien

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Protection phenotype: survival curve, weight-loss, and viral load of vaccinated (IM or IN) or unvaccinated (control treated) K18-hACE2^+/- transgenic mice. (A) Experimental scheme for evaluating the impact of route of vaccination on animal survival, weight loss, viral load, and disease pathology. (B) K18-hACE2^+/- mice were challenged with 2.5x10⁶ FFU of SARS-CoV-2 AZ1, and weight loss (mean +/- SEM) and survival were monitored. Weight loss was compared by one-way ANOVA, and survival was measured by the log-rank test. AdCOVID IM and IN each had significantly less weight loss than control. (**** p<0.0001) (C, D) Summary of infectious virus load from vaccinated and control K18-hACE2^+/- mice by FFA. (**** p<0.0001, *** p<0.001, ** p<0.01, * p<0.05, ns p>0.05 by Mann-Whitney test).