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. 2023 Aug 16;14:1188392. doi: 10.3389/fimmu.2023.1188392

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Copyright © 2023 Dickson, Geerling, Stone, Hassert, Steffen, Makkena, Smither, Schwetye, Zhang, Georges, Roberts, Suschak, Pinto and Brien

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Impact of hACE2 expression level on the susceptibility of K18-hACE2 transgenic mice. (A) Experimental scheme for evaluating the impact of hACE2 expression on animal survival, weight loss, and viral load. (B) K18-hACE2 ^{+/-, +/+} mice were challenged with decreasing doses of SARS-CoV-2 AZ1 starting at 2x10⁶ FFU and survival was monitored. (C) Body weight change over time and (D, E) infectious viral load in the lungs and brain were measured on days 4 and 6 post-infection. Weight change data are the mean +/- SEM comparing K18-hACE2^{+/+, +/-} groups. Viral levels were measured by FFA. Points show median values +/- Std Dev. (*** p<0.001, * p<0.05, ns p>0.05).