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. 2023 Aug 16;14:1188392. doi: 10.3389/fimmu.2023.1188392

Figure 7.

Figure 7

Impact of vaccination route on transmission in K18-hACE2+/+ transgenic mice. (A) Experimental scheme for measuring viral transmission from vaccinated mice to unvaccinated mice. (B) IM, IN, and Control-Contact, naïve mice, were monitored for animal survival for 21 days and weight loss. (C) Viral RNA levels in the NC were measured every other day for 9 days by RT-qPCR. (** p<0.01, * p<0.05, ns p>0.05 by Mann-Whitney test). (D) Percentage of IM, IN, and Control-contact animals that had detectible SARS-CoV-2 RNA in the NC measured every other day for 9 days by RT-qPCR. (** p<0.01, * p<0.05, ns p>0.05) Animal survival was measured by the log-rank test, viral RNA level was compared by the Mann-Whitney test, and the percentage of animals SARS-CoV-2+ was measured by the Fisher exact test.