Table 3.
Associations Between Bacterial Vaginosis Recurrence and Characteristics of the Vaginal Microbiota Pretreatment and Immediately Posttreatment
| Characteristic | Cure, Median (IQR)a | Recurrence, Median (IQR)a | AOR (95% CI)b | P Value |
|---|---|---|---|---|
| Compositional change (Bray–Curtis)c |
0.97 (0.82–0.99) | 0.88 (0.76–0.96) | 0.22 (.02–2.96) | .357 |
| Pretreatment (day 0) | ||||
| α-diversity (Shannon diversity) |
2.37 (1.83–2.73) | 2.49 (1.98–2.76) | 1.99 (.77–6.71) | .203 |
| Gardnerella spp | 7.07 (6.44–7.66) | 6.69 (6.44–7.09) | 1.15 (.80–1.86) | .514 |
| Prevotella sppd | 4.99 (2.44–6.03) | 5.92 (5.52–6.54) | 1.35 (1.05–1.91) | .041 |
| Lactobacillus crispatus | −0.86 (−1.22 to −0.51) | −0.88 (−1.13 to −0.44) | 0.89 (.52–1.25) | .576 |
| Lactobacillus fornicalis | −0.87 (−1.23 to −0.56) | −0.88 (−1.13 to −0.44) | 0.78 (.33–1.25) | .418 |
| Immediately posttreatment (day 8) | ||||
| α-diversity (Shannon diversity) |
0.72 (0.36–1.17) | 0.81 (0.28–1.49) | 1.37 (.60–2.97) | .435 |
| Gardnerella spp | 2.33 (−0.17 to 5.18) | 5.41 (1.18–7.83) | 1.23 (1.03–1.49) | .026 |
| Prevotella sppd | −0.22 (−0.36 to −0.11) | −0.20 (−0.38 to −0.13) | 1.00 (.72–1.31) | .983 |
| Lactobacillus crispatus | −0.22 (−0.48 to −0.11) | −0.30 (−0.52 to −0.16) | 0.71 (.29–1.03) | .228 |
| Lactobacillus fornicalis | −0.18 (−0.39 to −0.08) | −0.30 (−0.52 to −0.16) | 0.67 (.30–1.03) | .168 |
P values <.05 are bolded to indicate statistically significant associations.
Abbreviations: AOR, adjusted odds ratio; CI, confidence interval; IQR, interquartile range.
Values for individual bacterial taxa represent the centered log-ratio transformed abundance.
Regression models were adjusted for partner type (treated regular sexual partner [RSP], untreated RSP, no RSP) and laboratory method.
Compositional change was measured using Bray–Curtis distances calculated between paired pretreatment and immediate posttreatment samples, where a value of 0 indicates no compositional change following treatment and a value closer to 1 indicates substantial change following treatment. Only women who provided both day 0 and day 8 samples (n = 109) were included in this analysis.
Represents Prevotella amplicon sequence variants that were not able to be classified at the species level.