Table 2.

A table summarizing the function of different RGS proteins in female disorders/diseases discussed in this paper

Disease	RGS protein	Mechanisms	References
Ovarian carcinoma	RGS2 RGS5 RGS10 RGS17	Accumulation of DNMT1 and class I HDACs Histone modifications and DNA methylation To regulate PI3K/AKT survival pathway	[24–26, 30, 34]
Hysteromyom	RGS2 RGS6	To reduce the endogenous levels of progesterone	[39, 42, 44]
Gestational hypertension	RGS2	To restrain Gαq signaling in vascular smooth muscle To regulate Gαi/o signaling in the vascular endothelium To alter Gαs signaling	[55, 72]
Preeclampsia	RGS2	SNP (rs4606) is correlated with an increased risk in PE development To activate Gq-coupled AT1 receptors, ANG II can trigger vasoconstriction To regulate trophoblast cells epithelial-mesenchymal transition Regulated by hypoxia that contributes to PE	[78, 89, 90]
Postpartum Depression	RGS2	Knockdown of Rgs2 reinforces the 5-HT levels in hippocampal CA1 neurons Silencing of Rgs2 accelerates the cAMP pathway activation	[96, 98]
Breast cancer	RGS2 RGS16	miR-183-5p promotes BC progression through RGS2 DNA methylation by microdeletions in the RGS16 promoter region (1q25.3)	[12, 100]
Pulmonary Hypoplasia	RGS2	To repress signals such as duration and amplitude To reduce thrombin-induced intracellular Ca2 + signaling	[105, 106, 109]