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. 2023 Aug 22;26(4):474. doi: 10.3892/etm.2023.12173

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Copyright: © Xie et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Nr2c2 overexpression reverses the elevated proportion of CD44⁺CD24^-/low cells and the increased migratory ability originally induced by ^nr2e3 silencing. (A) Flow cytometry was used to analyze the proportion of CD44⁺CD24^-/low subgroups in nr2c2-overexpressing MCF7 tumor cells with nr2e3 expression knocked down. (B) Semi-quantification of the CD44⁺CD24^-/low ratio in (A). (C) Migratory activity of MCF7 cells following nr2c2 overexpression and nr2e3 silencing was analyzed using Transwell assay. The migratory cells were observed using an Olympus CKX53 inverted microscope at x200 magnification. Scale bar, 100 µm. ^**P<0.01. sh, short hairpin RNA; NR2C2, nuclear receptor subfamily 2 group C member 2; NR2E3, nuclear receptor subfamily 2 group E member 3.