REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Anti-beta III Tubulin antibody [2G10] - Neuronal Marker ab78078	abcam	Cat#ab78078 RRID: AB_2256751
Anti-IL10 Antibody	abcam	Cat#ab189392 RRID:AB_2847946
goat anti-mouse IgG-HRP: sc-2005	Santa Cruz Biotechnology	Cat#sc-2005 RRID: AB_631736
Goat Anti-Rat IgG H&L (Alexa Fluor® 488)	abcam	Cat#ab150165 RRID:AB_2650997
Alexa Fluor® 647 AffiniPure Rabbit Anti-Mouse IgG (H + L)	Jackson ImmunoResearch Inc.	Code number:315-605-045 RRID: AB_2340244
Bacterial and virus strains
Bacteroides.thetaiotaomicron VPI 5482	Gao’s laboratory	ATCC 29148
Chemicals, peptides, and recombinant proteins
Dextran sulfate sodium salt	MP Biomedicals	Cat#160110
Azoxymethane	Sigma Aldrich	Cat# A5486
Collagenase Type IV	Sigma Aldrich	Cat# C4-28
Protease Inhibitor Cocktail (EDTA-Free)	MedChemExpress	Cat# HY-K0011
Fetal Bovine Serum	ExCell Bio	Cat# FSP500
DMEM high glucose	Thermo Fisher Scientific	Cat# C11965500BT
Penicillin-Streptomycin Solution	Thermo Fisher Scientific	Cat#15140122
Trizol Reagent	Thermo Fisher Scientific	Cat#15140122
Neurobasal™ Plus	Thermo Fisher Scientific	Cat#A3582901
Recombinant Murine GDNF	PEPROTECH	Cat#450-44
B-27™ Supplement (50X), serum free	Thermo Fisher Scientific	Cat#17504044
Hoechst 33258	Thermo Fisher Scientific	Cat#H1398
chondroitinase ABC	Sigma Aldrich	Cat#C2905
sodium propionate	MedChemExpress	Cat#137-4-6
Critical commercial assays
ELISA Kit for Chondroitin Sulfate (CS)	CLOUD-CLONE-CORP.WUHAN	Cat#CEA723Ge
One Step Mouse Genotyping Kit	Vazyme	Cat#PD101-01
ChamQ Universal SYBR qPCR Master Mix	Vazyme	Cat# Q711
HiScript® III RT SuperMix for qPCR (+gDNA wiper)	Vazyme	Cat#R323
Deposited data
Mouse fecal 16S rRNA data	This paper	PRJNA803604 https://www.ncbi.nlm.nih.gov/bioproject
RNA-Seq sequencing data	This paper	PRJNA803604 https://www.ncbi.nlm.nih.gov/bioproject
Experimental models: Cell lines
HCT116	ATCC	CCL-247
MC38	Provided by Prof. Chuanping Si (Institue of Immunology and Molecular Medicine, Jining Medical College)	RRID:CVCL_B288
Experimental models: Organisms/strains
Mouse: B6: C57BL/6J	Animal core facility of Nanjing medical university	N/A
Oligonucleotides
Primers for qPCR: see Table S1	This paper	N/A
Recombinant DNA
(BGN)TK-PCDH-copGFP-T2A-Puro	This paper	N/A
Software and algorithms
GraphPad Prim 6.0	GraphPad Software	https://www.graphpad.com/
QIIME 2	Bolyen, et al., 201941	https://docs.qiime2.org/2020.8/
R	R Core Team	https://www.r-project.org/
Fastqc	Babraham Bioinformatics	https://github.com/DaehwanKimLab/hisat2
PICRUSt 2	Gavin M. Douglas, et al., 202042	https://github.com/picrust/picrust2
STAMP 2.1.3	Donovan H Parks, et al.43	http://kiwi.cs.dal.ca/Software/STAMP
usearch v11.0.667_i86linux32	Robert C. Edgar, et al.44	http://www.drive5.com/usearch
vsearch v2.17.1_linux_x86_64	Torbjørn Rognes, et al.45	https://github.com/torognes/vsearch
GTDB	Donovan H Parks, et al.,202024	https://gtdb.ecogenomic.org
eggNOG 5.0	Jaime Huerta-Cepas, et al.46	http://eggnog.embl.de
MEME Suite	Timothy L Bailey, et al.47	http://meme-suite.org
Pfam	Jaina Mistry, et al.48	http://pfam.xfam.org/
MEGA software	Sudhir Kumar, et al.49	www.megasoftware.net
Clustal X2	M A Larkin, et al.50	http://www.ebi.ac.uk/tools/clustalw2; ftp://ftp.ebi.ac.uk/pub/software/clustalw2/
All original code	This paper	https://github.com/Xingyinliu-Lab/BGN-project-related-codes
Mendeley data	This paper	https://doi.org/10.17632/4bk37hy3r3.1