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. 2023 Aug 17;14:1184776. doi: 10.3389/fphar.2023.1184776

FIGURE 3.

FIGURE 3

The result of Y-maze tests and Western blot analyses of PSD-95 and p-CaMKII on days 1, 3, and 7 after treatment with Dex or saline intraperitoneally (A) A significant decrease in the percentage of alternation was observed in the Aβ group compared to that in the control, and a significant recovery of the behavior was observed in the Aβ/D40 group on days 1, 3, and 7. There was no significant difference in the results among the saline ic.v. groups (control, D40, and D80). (B) On days 1, 3, and 7, the intensity of PSD-95 levels decreased significantly in the Aβ group compared to those in the control. The reversed intensity of PSD-95 was observed in the Aβ/D40 group on days 1, 3, and 7. (C) The intensity of p-CaMKII levels increased substantially in the Aβ group compared to those in the control on days 1, 3, and 7. A significant decrease in the intensity of p-CaMKII was observed in the Aβ/D40, and Aβ/D80 groups compared to that in the Aβ group on days 1, 3, and 7. Data are presented as the mean ± SEM. *p < 0.05, compared to the control, † p < 0.05, compared to the Aβ group.