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. 2023 Aug 17;13:1205348. doi: 10.3389/fcimb.2023.1205348

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Copyright © 2023 Shi, Li, Cai, Zhao, Zhao, Sun and Yang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Linear discriminant analysis effect size (LEfSe) analysis of taxonomic features differentiating in gastric mucosal mycobiota between the nt-GERD group and the s-PPI group (A) and l-PPI group (B) (LDA values >2, p < 0.08) at the genus level. Differentially abundant taxa of each group are distinguished by different colors. Candida increased in patients treated with PPIs (C). At the genus level, the abundance of Candida in patients treated with PPIs (s-PPI and l-PPI group) was significantly higher than in the nt-GERD group and healthy controls (C).