Skip to main content
. 2023 Jun 30;12(15):16337–16358. doi: 10.1002/cam4.6256

FIGURE 8.

FIGURE 8

PHGDH is associated with glutamine metabolism and highly expressed in EC. (A) Co‐expression and interacting gene network of five key genes. PHGDH may co‐expressed and physically interacted with ASNS. (B) Single gene enrichment analysis showed positive relationship with PHGDH and aspartate and glutamate metabolism. (C) Survival analysis based on the protein expression of PHGDH from HPA database on EC patients. (D) ROC analysis of PHGDH on EC prognosis prediction. (E) The expression of PHGDH in paired tumor and para‐tumoral tissues from our hospital by IHC and the statistical analysis of the percentage of positive cells (F). (G) The expression of PHGDH in seven endometrial carcinoma cell lines. (H) WB and (I) RT‐PCR was conducted to confirm PHGDH silencing by comparison to the corresponding negative control (NC). *p < 0.05, **p < 0.01.