Table 2.
Mendelian randomisation (MR) results of causal effects between gut microbiome and the risk of fracture.
| Group | Bacterial traits | Nsnp | Methods | SE | OR (95% CI) | p-value |
|---|---|---|---|---|---|---|
| Class | Mollicutes | 12 | MR Egger | 0.009 | 0.992 (0.974, 1.010) | 0.400 |
| Weighted median | 0.004 | 0.994 (0.986, 1.002) | 0.140 | |||
| Inverse variance weighted | 0.003 | 0.994 (0.988, 0.999) | 0.022 | |||
| Simple mode | 0.006 | 0.993 (0.981, 1.005) | 0.301 | |||
| Weighted mode | 0.006 | 0.995 (0.983, 1.006) | 0.374 | |||
| Family | Defluviitaleaceae | 12 | MR Egger | 0.008 | 1.006 (0.990, 1.021) | 0.494 |
| Weighted median | 0.003 | 1.005 (0.998, 1.011) | 0.149 | |||
| Inverse variance weighted | 0.002 | 1.005 (1.001, 1.010) | 0.022 | |||
| Simple mode | 0.005 | 1.006 (0.995, 1.016) | 0.324 | |||
| Weighted mode | 0.005 | 1.005 (0.995, 1.015) | 0.359 | |||
| Family | Bacteroidales S24.7 group | 9 | MR Egger | 0.016 | 1.019 (0.988, 1.051) | 0.277 |
| Weighted median | 0.004 | 1.004 (0.997, 1.011) | 0.245 | |||
| Inverse variance weighted | 0.003 | 1.007 (1.000, 1.013) | 0.049 | |||
| Simple mode | 0.006 | 1.003 (0.992, 1.015) | 0.554 | |||
| Weighted mode | 0.005 | 1.002 (0.991, 1.012) | 0.776 | |||
| Genus | Allisonella | 8 | MR Egger | 0.014 | 1.007 (0.980, 1.036) | 0.613 |
| Weighted median | 0.002 | 1.003 (0.998, 1.008) | 0.272 | |||
| Inverse variance weighted | 0.002 | 1.005 (1.001, 1.009) | 0.015 | |||
| Simple mode | 0.004 | 1.002 (0.995, 1.009) | 0.597 | |||
| Weighted mode | 0.004 | 1.002 (0.995, 1.009) | 0.562 | |||
| Genus | Collinsella | 10 | MR Egger | 0.014 | 0.994 (0.967, 1.021) | 0.656 |
| Weighted median | 0.005 | 0.994 (0.985, 1.003) | 0.169 | |||
| Inverse variance weighted | 0.004 | 0.993 (0.986, 1.000) | 0.047 | |||
| Simple mode | 0.007 | 0.994 (0.980, 1.008) | 0.421 | |||
| Weighted mode | 0.007 | 0.995 (0.981, 1.008) | 0.477 | |||
| Genus | Defluviitaleaceae UCG011 | 10 | MR Egger | 0.009 | 1.002 (0.984, 1.020) | 0.838 |
| Weighted median | 0.004 | 1.006 (0.999, 1.014) | 0.070 | |||
| Inverse variance weighted | 0.003 | 1.006 (1.001, 1.011) | 0.019 | |||
| Simple mode | 0.006 | 1.008 (0.995, 1.021) | 0.239 | |||
| Weighted mode | 0.006 | 1.006 (0.994, 1.018) | 0.331 | |||
| Phylum | Tenericutes | 12 | MR Egger | 0.009 | 0.992 (0.974, 1.010) | 0.400 |
| Weighted median | 0.004 | 0.994 (0.987, 1.001) | 0.114 | |||
| Inverse variance weighted | 0.003 | 0.994 (0.988, 0.999) | 0.022 | |||
| Simple mode | 0.007 | 0.993 (0.981, 1.066) | 0.331 | |||
| Weighted mode | 0.006 | 0.995 (0.982, 1.007) | 0.416 |
SNP, single nucleotide polymorphism; MR, mendelian randomization; SE, standard error; 95% CI, 95% confidence interval.