Table 5.

Mendelian randomisation (MR) results of causal effects between gut microbiome and appendicular lean mass.

Group	Bacterial traits	Nsnp	Methods	SE	β (95% CI)	p-value
Family	Bacteroidaceae	9	MR Egger	0.086	0.008 (−0.160, 0.176)	0.927
			Weighted median	0.017	0.022 (−0.012, 0.056)	0.197
			Inverse variance weighted	0.015	0.041 (0.010, 0.071)	0.008
			Simple mode	0.025	0.019 (−0.031, 0.069)	0.478
			Weighted mode	0.021	0.017 (−0.025, 0.058)	0.456
Genus	Eubacterium fissicatena group	9	MR Egger	0.047	−0.047 (−0.139, 0.046)	0.353
			Weighted median	0.009	−0.022 (−0.039, −0.006)	0.009
			Inverse variance weighted	0.008	−0.017 (−0.034, −0.000)	0.044
			Simple mode	0.013	−0.024 (−0.049, 0.002)	0.103
			Weighted mode	0.012	−0.023 (−0.047, 0.001)	0.095
Genus	Bacteroides	9	MR Egger	0.086	0.008 (−0.160, 0.176)	0.927
			Weighted median	0.018	0.022 (−0.013, 0.057)	0.215
			Inverse variance weighted	0.015	0.041 (0.010, 0.071)	0.008
			Simple mode	0.025	0.019 (−0.031, 0.068)	0.477
			Weighted mode	0.023	0.017 (−0.029, 0.062)	0.492
Genus	Lachnospira	6	MR Egger	0.098	0.186 (−0.007, 0.379)	0.132
			Weighted median	0.020	0.036 (−0.003, 0.075)	0.072
			Inverse variance weighted	0.019	0.037 (0.000, 0.073)	0.049
			Simple mode	0.028	0.033 (−0.022, 0.087)	0.290
			Weighted mode	0.027	0.032 (−0.020, 0.084)	0.281
Genus	Phascolarctobacterium	11	MR Egger	0.053	0.022 (−0.082, 0.125)	0.689
			Weighted median	0.013	0.014 (−0.011, 0.039)	0.279
			Inverse variance weighted	0.011	0.024 (0.002, 0.046)	0.031
			Simple mode	0.018	0.017 (−0.017, 0.052)	0.347
			Weighted mode	0.018	0.017 (−0.018, 0.052)	0.358

SNP, single nucleotide polymorphism; MR, mendelian randomization; SE, standard error; 95% CI, 95% confidence interval.