Table 6.

Mendelian randomisation (MR) results of causal effects between gut microbiome and the risk of low back pain.

Group	Bacterial traits	Nsnp	Methods	SE	OR (95% CI)	p-value
Class	Melainabacteria	10	MR Egger	0.161	0.848 (0.618, 1.162)	0.334
			Weighted median	0.066	0.934 (0.820, 1.063)	0.301
			Inverse variance weighted	0.050	0.891 (0.808, 0.984)	0.022
			Simple mode	0.097	0.936 (0.774, 1.131)	0.509
			Weighted mode	0.085	0.927 (0.784, 1.096)	0.396
Family	Prevotellaceae	16	MR Egger	0.251	1.316 (0.804, 2.151)	0.293
			Weighted median	0.086	1.149 (0.970, 1.362)	0.107
			Inverse variance weighted	0.066	1.182 (1.038, 1.346)	0.012
			Simple mode	0.157	1.139 (0.837, 1.551)	0.421
			Weighted mode	0.154	1.125 (0.831, 1.522)	0.459
Genus	Oxalobacter	11	MR Egger	0.187	1.037 (0.719, 1.496)	0.848
			Weighted median	0.053	1.130 (1.018, 1.254)	0.022
			Inverse variance weighted	0.040	1.151 (1.065, 1.245)	<0.001
			Simple mode	0.099	1.050 (0.864, 1.276)	0.634
			Weighted mode	0.086	1.057 (0.893, 1.252)	0.534
Genus	Tyzzerella3	13	MR Egger	0.241	1.053 (0.656, 1.690)	0.834
			Weighted median	0.055	1.123 (1.009, 1.251)	0.035
			Inverse variance weighted	0.042	1.121 (1.032, 1.217)	0.007
			Simple mode	0.087	1.124 (0.948, 1.332)	0.203
			Weighted mode	0.086	1.128 (0.953, 1.336)	0.186

SNP, single nucleotide polymorphism; MR, mendelian randomization; SE, standard error; 95% CI, 95% confidence interval.