Table 9.

Sensitivity analysis of the Mendelian randomization (MR) analysis results of gut microbiota and musculoskeletal diseases.

Outcome	Bacterial traits	Cochran Q statistic	Heterogeneity p-value	MR-Egger Intercept	Intercept p-value	MR-PRESSO Global test p-value
Osteoporosis	NB1n	4.318	0.987	0.000	0.413	0.987
	Lachnospiraceae NK4A136 group	11.362	0.581	0.000	0.086	0.514
	Howardella	5.752	0.765	−0.001	0.28	0.77
	Christensenellaceae R.7 group	10.056	0.3	0.000	0.55	0.36
	Eubacterium oxidoreducens group	4.423	0.3	0.00	0.673	0.41
Fracture	Mollicutes	10.467	0.48	0.00	0.848	0.50
	Defluviitaleaceae	13.793	0.245	0.00	0.573	0.26
	Bacteroidales S24.7 group	12.199	0.14	−0.0	0.4	0.18
	Allisonella	7.713	0.3	0.0	0.8	0.39
	Collinsella	3.987	0.91	0.00	0.9	0.92
	Defluviitaleaceae UCG011	8.947	0.44	0.00	0.6	0.46
	Tenericutes	10.467	0.489	0.000	0.848	0.521
Hand grip strength (Right)	Actinobacteria	43.759	0.119	0.002	0.360	0.209
	Bifidobacteriaceae	58.911	0.148	−0.009	0.177	0.451
	Alloprevotella	3.621	0.605	−0.001	0.871	0.645
	Bifidobacterium	48.382	0.268	−0.001	0.969	0.327
	Eisenbergiella	12.407	0.259	−0.004	0.372	0.280
	Parabacteroides	2.356	0.798	0.002	0.592	0.803
	Paraprevotella	7.685	0.809	0.001	0.721	0.809
	Prevotella9	21.374	0.092	0.002	0.441	0.098
	Sellimonas	8.671	0.371	−0.000	0.865	0.394
	Actinobacteria	12.803	0.119	0.002	0.702	0.308
Hand grip strength (Left)	Bifidobacteriaceae	60.348	0.799	−0.009	0.126	0.782
	Eubacterium nodatum group	9.233	0.510	−0.000	0.908	0.530
	Bifidobacterium	50.120	0.133	0.001	0.847	0.100
	Olsenella	18.383	0.488	0.003	0.305	0.066
	Parabacteroides	5.492	0.359	−0.001	0.728	0.446
	Sellimonas	6.242	0.620	0.000	0.990	0.651
	Bifidobacteriales	60.348	0.799	−0.009	0.126	0.762
Appendicular lean mass	Bacteroidaceae	12.005	0.151	0.002	0.711	0.195
	Eubacterium fissicatena group	16.318	0.380	0.004	0.540	0.517
	Bacteroides	12.005	0.151	0.002	0.711	0.175
	Lachnospira	7.805	0.167	−0.009	0.141	0.231
	Phascolarctobacterium	13.400	0.145	−0.001	0.825	0.174
Low back pain	Melainabacteria	9.168	0.422	−0.006	0.749	0.473
	Prevotellaceae	19.450	0.194	0.014	0.448	0.200
	Oxalobacter	6.227	0.796	−0.016	0.583	0.836
	Tyzzerella3	11.783	0.945	0.007	0.762	0.953
Rheumatoid arthritis	Clostridia	6.466	0.595	−0.010	0.819	0.649
	Christensenellaceae	0.309	1.000	0.003	0.916	1.000
	Clostridialesvadin BB60 group	8.826	0.638	0.008	0.698	0.653
	Desulfovibrionaceae	4.510	0.808	0.004	0.876	0.824
	Oxalobacteraceae	5.470	0.906	0.002	0.968	0.937
	Streptococcaceae	10.513	0.571	−0.013	0.734	0.600
	Desulfovibrio	10.225	0.250	0.017	0.583	0.287
	Oxalobacter	0.808	4.515	−0.012	0.825	0.819
	Ruminococcaceae UCG002	18.311	0.369	0.066	0.021	0.388
	Ruminococcaceae UCG013	12.877	0.116	−0.019	0.685	0.134
	Turicibacter	5.330	0.722	0.000	0.993	0.736
	Bacillales	2.280	0.809	0.007	0.855	0.840
	Clostridiales	6.184	0.721	0.003	0.939	0.760
	Cyanobacteria	6.867	0.333	0.009	0.862	0.422
Ankylosing spondylitis	Lactobacillaceae	4.146	0.844	0.016	0.710	0.843
	Rikenellaceae	10.762	0.904	−0.009	0.814	0.903
	Ruminococcaceae NK4A214 group	13.561	0.405	−0.073	0.126	0.443
	Howardella	6.444	0.598	0.042	0.542	0.543
	Anaerotruncus	10.645	0.560	0.063	0.138	0.582

MR-Egger, Mendelian randomization Egger.