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. 2023 Aug 31;11:141. doi: 10.1186/s40478-023-01631-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — Western blot profiles of sCJDMV resPrP^Sc. Only the unglycosylated isoform of resPrP^Sc is shown for convenience. a 1C histotype with short disease duration harbors T1²⁰; control (ctl): T1²⁰-T2. b(i) 1C-2PL featuring T1²⁰ in the cerebral cortex, and T1²⁰ co-existing with a minor T1²¹ fragment in subcortical regions; ctl: T1²¹. b(ii) T2 is detected in the entorhinal corte (EC), and subcortical regions. c(i) In 1C-2K T1²⁰ is detected in all brain regions, T1²⁰-T2 in the SN; Ctl: T1²¹. c(ii) T2 is detected in the EC, occipital cortex (OC), and subcortical regions; ctl: T2. d 2C with “pure” T2 detected in all brain regions; ctl: T1²⁰; arrowhead: lower resPrP^Sc fragment of ~ 18 kDa. e 2C-PL with co-existing T1²¹ and T1²⁰ variants, and predominant of T1²¹; ctl: T1²⁰. f 2C-K with predominant T1²¹ in hippocampus (HI), and predominant T1²⁰ in the EC, and subcortical regions; ctl: T1²⁰; arrowhead: lower resPrP^Sc fragment of ~ 18 kDa. g 2K featuring T1²⁰-T2 with a prominent T2 in cerebral cortex; inset: shorter time of film exposure. FC_s: frontal cortex, superior gyrus; FC_M: FC, middle gyrus; TC: temporal cortex; PC: pariental cortex; VC: visual cortex; ST: striatum; anterior thalamus (TH); substantia nigra (SN) of midbrain; CE: cerebellum. d–g Percentage of cortical coarse PrP is indicated in green