. 2023 Jun 23;8(4):e00678-22. doi: 10.1128/msystems.00678-22

TABLE 3.

Comparison of differentially abundant human proteins in BV identified by past studies with results of Hybrid_Sample-Matched database searches ^a

Protein	This study		Past studies
Protein	P-value	Higher/lower in BV	Higher/lower in BV	Reference
Elafin	>0.1			Stock et al. (51)
Muc5B	<0.05			Borgdorff et al. (52)
Muc5AC	<0.05			Borgdorff et al. (52)
Calprotectin	>0.1			Borgdorff et al. (52)
Complement factor 3	>0.1			Borgdorff et al. (52)
Migration inhibitory factor	>0.1			Borgdorff et al. (52)
Cystatin A	<0.01			Borgdorff et al. (52)
Cystatin A	<0.01			Ferreira et al. (54)
Lysozyme C	>0.1			Borgdorff et al. (52)
Serine protease inhibitor kazal type 5	<0.1			Borgdorff et al. (52)
Involucrin	<0.01			Zevin et al. (53)
Involucrin	<0.01			Ferreira et al. (54)
Cornifin-A	<0.05			Zevin et al. (53)
Cathepsin G	>0.1			Ferreira et al. (54)
Neutrophil elastase	>0.1			Ferreira et al. (54)
Neutrophil defensin 1	>0.1			Ferreira et al. (54)
Leukocyte elastase inhibitor	<0.01			Ferreira et al. (54)
Histone H4	>0.1			Ferreira et al. (54)
SPR3	<0.01			Ferreira et al. (54)
Cornifin-B	<0.01			Ferreira et al. (54)
SPR2A	>0.1			Ferreira et al. (54)
Repetin	>0.1			Bradley et al. (55)
Keratin 6A	>0.1			Bradley et al. (55)
Keratin 16	<0.01			Bradley et al. (55)
Suprabasin	<0.01			Bradley et al. (55)

^{^a}

Human proteins were found to be differentially abundant in BV in past metaproteomic studies compared with results from this investigation. Mann-Whitney U tests were performed on theresults of Hybrid_Sample-Matched database searches and significance levels are shown. Each cell in the table specifies whether the protein had a higher (orange up-arrow) or lower (blue down-arrow) abundance in BV+ samples compared to BV− samples.