Table 2.
New putative T6SS effectors and cognate immunity proteins encoded in SPI-6 of Salmonella enterica.
| T6SS effector genes | Cognate T6SS immunity protein genes | |||||
|---|---|---|---|---|---|---|
| ORF(s) | Size (aa) | Serotype-strain | Variable region | Predicted activity/domain | ORF(s) | TM or signal peptide/domain |
| Effectors targeting peptidoglycan | ||||||
| Unannotated ORF | 32 | S. Bareilly RSE03 | 1 | Peptidoglycan hydrolase (Amidase)/L-Ala, D-Glu endopeptidase | ELZ70_17800 | Signal peptide (Sec/SPI)/No |
| S. Bredeney CVM24358 | HFS03_00580 | |||||
| S. Daytona NCTC7102 | NCTC7102_04795 | |||||
| S. Florida NCTC6480 | NCTC6480_03851 | |||||
| S. Give NCTC5778 | NCTC5778_03432 | |||||
| S. India SA20085604 | Unannotated ORF | |||||
| S. Mikawasima RSE13 | Unannotated ORF | |||||
| S. Paratyphi A ATCC9150 | SPA_RS12640 | |||||
| S. Poona NCTC4840 | NCTC4840_03690 | |||||
| S. enterica LHST_2018 | Unannotated ORF | |||||
| S. enterica NCTC7404 | NCTC7404_03579 | |||||
| S. enterica NCTC7411 | NCTC7411_03668 | |||||
| S. enterica NCTC7831 | NCTC7831_03115 | |||||
| S. enterica NCTC8272 | NCTC8272_03056 | |||||
| S. Sanjuan NCTC7406 | NCTC7406_04092 | |||||
| S. Schwarzengrund CMV19633 | SESA_RS02015 | |||||
| S. Senftenberg ATCC 43845 | SEES3845_018760 | |||||
| S. Typhi CT18 | STY_RS01380 | |||||
| NCTC7406_04082 | 122 | S. Sanjuan NCTC7406 | 2 | Peptidoglycan hydrolase (L,D transpeptidase)/Pgp2 | NCTC7406_04081 | Signal peptide (Sec/SPI)/No |
| G9X22_18260 | 279 | S. Adjame 353,868 | 2 | Peptidoglycan hydrolase (Amidase)/TseH-like | Unannotated ORF | 2 TM/DUF4229 |
| NCTC5778_03416 | S. Give NCTC5778 | NCTC5778_03415 | ||||
| LFZ16_04210 | S. India SA20085604 | LFZ16_04215 | ||||
| SESA_RS02090 | S. Schwarzengrund CMV19633 | Unannotated ORF | ||||
| SESEF3709_03438 | 243 | S. enterica SESen3709 | 2 | Peptidoglycan hydrolase (Amidase)/Reprolysin_4 | SESEF3709_03437 | Signal peptide (Sec/SPI)/No |
| EOS97_RS15095 | Salmonella sp. SSDFZ54 | EOS97_RS15100 | No/No | |||
| SEES3845_018655 | S. Senftenberg ATCC 43845 | SEES3845_018650 | No/No | |||
| CS349_18880 | S. Tennessee CFSAN070645 | CS349_18875 | No/No | |||
| NCTC7411_03656 | 243 | S. enterica NCTC7411 | 2 | Peptidoglycan hydrolase (Amidase)/Peptidase_M64 | NCTC7411_03655 | 1 TM/No |
| NCTC7831_03138 | S. enterica NCTC7831 | NCTC7831_03139 | 1 TM/No | |||
| NCTC7406_04078 | S. Sanjuan NCTC7406 | NCTC7406_04077 | 1 TM/No | |||
| Effectors targeting nucleic acids | ||||||
| Unannotated ORF | 149 | S. Kedougo Sal162 | 3 | RNase and DNase/RhsA-Ntox47-Tox-HNH-EHHH | Unannotated ORF | No/Imm50 |
| CS349_18795 | S. Tennessee CFSAN070645 | CS349_18790 | ||||
| NCTC7836_04182 | 970 | S. enterica NCTC7836 | 3 | DNase/RhsA-PDEEXK | NCTC7836_04181 | No/No |
| NCTC7836_04194 | 616 | S. enterica NCTC7836 | 3 | DNase/RhsA-Tox-HNH-EHHH | NCTC7836_04193 | No/No |
| NCTC8272_03019 | 589 | S. enterica NCTC8272 | NCTC8272_03018 | No/No | ||
| SESEF3709_03428 | 592 | S. enterica SESen3709 | SESEF3709_03427 | No/Imm50 | ||
| G9X22_18245 | 1,501 | S. Adjame 353,868 | 3 | DNase/PAAR-RhsA-Tox-HNH-EHHH | G9X22_18240 | No/Imm50 |
| CFSAN002050_RS06455 | 1,499 | S. Cubana CFSAN002050 | CFSAN002050_RS06460 | No/No | ||
| HFQ57_17525 | S. Havana CVM20761 | HFQ57_17520 | No/No | |||
| SEES3845_018630 | S. Senftenberg ATCC 43845 | Unannotated ORF | No/No | |||
| HFQ45_19990 | 1,377 | S. Anatum CVM20746 | 3 | DNase/PAAR-RhsA-HNHc | HFQ45_19995 | No/SMI1_KNR4 |
| NCTC5778_03412 | 1,382 | S. Give NCTC5778 | NCTC5778_03411 | No/SMI1_KNR4 | ||
| E4T58_01505 | 1,580 | S. Infantis L41 | E4T58_01510 | No/No | ||
| SPA_RS12520 | 1,570 | S. Paratyphi A ATCC9150 | SPA_RS12515 | No/No | ||
| NCTC7831_03143 | 1,382 | S. enterica NCTC7831 | NCTC7831_03144 | No/SMI1_KNR4 | ||
| SEES3845_018590 | 1,377 | S. Senftenberg ATCC 43845 | SEES3845_018585 | No/SMI1_KNR4 | ||
| NCTC7102_04762 | 1,044 | S. Daytona NCTC7102 | 3 | DNase/RhsA-WHH | NCTC7102_04761 | No/SMI1_KNR4 |
| SESEF3709_03422 | 1,575 | S. enterica SESen3709 | 3 | DNase/PAAR-RhsA-WHH | SESEF3709_03421 | No/SMI1_KNR4 |
| ELZ70_17690 | 1,354 | S. Bareilly RSE03 | 3 | DNase/PAAR-RhsA-AHH | ELZ70_17685 | No/No |
| HFQ57_17490 | 1,368 | S. Havana CVM20761 | HFQ57_17485 | |||
| HI825_06260 | 1,317 | S. enterica LHST_2018 | HI825_06265 | |||
| STY_RS01485 | 1,354 | S. Typhi CT18 | STY_RS01490 | |||
| HF553_RS18710 | 1,374 | Salmonella sp. SCFS4 | 3 | DNase/PAAR-RhsA-GIY-YIG | HF553_RS18705 | No/CdiI |
| HU143_RS17590 | Salmonella sp. SJTUF14076 | HU143_RS17585 | ||||
| IVP14_RS17960 | Salmonella sp. SJTUF14146 | IVP14_RS17955 | ||||
| IVP15_RS18860 | Salmonella sp. SJTUF14152 | IVP15_RS18855 | ||||
| IVP16_RS17665 | Salmonella sp. SJTUF14154 | IVP16_RS17660 | ||||
| IVP17_RS17925 | Salmonella sp. SJTUF14170 | IVP17_RS17920 | ||||
| IVP18_RS17920 | Salmonella sp. SJTUF14178 | IVP18_RS17915 | ||||
| HFQ45_20000 | 174 | S. Anatum CVM20746 | 3 | RNase/RhsA-DUF4329 | HFQ45_20005 | No/CdiI |
| ELZ68_18315 | 267 | S. Stanleyville RSE01 | ELZ68_18310 | No/No | ||
| SCH_RS26875 | 1,593 | S. Choleraesuis SC-B67 | 3 | RNase/PAAR-RhsA-DUF4329 | SCH_RS01475 | No/CdiI |
| SPC_RS25995 | S. Paratyphi C RSK4594 | SPC_RS01475 | ||||
| NCTC13175_03561 | 352 | S. Goldcoast NCTC13175 | 3 | RNase/RhsA-Ribonuclease/Microbial Rnase | NCTC13175_03560 | No/Barstar |
| Unannotated ORF | 1,564 | S. Derby Sa64 | 3 | RNase/PAAR-RhsA-Ribonuclease/Microbial Rnase | EIC79_17405 | No/Barstar |
| SEBLO3795_03484 | 1,564 | S. enterica SEHaa3795 | SEBLO3795_03483 | |||
| EOS98_RS24920 | 1,560 | Salmonella sp. SSDFZ69 | EOS98_RS17735 | |||
| HLB37_13055 | 1,560 | S. Kedougo Sal162 | 3 | RNase/PAAR-RhsA-EndoU_bacteria | HLB37_13060 | No/MafI |
| SEHA_RS26915 | 102 | S. Heidelberg SL476 | 3 | RNase/CdiA | SEHA_RS02130 | No/Imm42 |
| IA1_RS24740 | S. Thompson RM6836 | IA1_RS01635 | ||||
| HI825_06280 | 106 | S. enterica LHST_2018 | 3 | Deaminase/Tox-Deaminase | HI825_06285 | No/SUKH_5 |
| STY_RS01505 | 86 | S. Typhi CT18 | STY_RS01510 | |||
| Effectors targeting translation machinery | ||||||
| DYN42_004080 | 943 | S. London CVM N17S347 | 3 | ADP-ribosyltransferase/RhsA-Tox-ART-HYD1 | DYN42_004085 | No/No |
| NCTC8271_04564 | 194 | S. enterica NCTC8271 | Unannotated ORF | |||
| NCTC5741_00975 | 943 | S. enterica NCTC5741 | NCTC5741_00976 | |||
| SESEF3709_03418 | 402 | S. enterica SESen3709 | SESEF3709_03417 | |||
| IA1_RS01605 | 959 | S. Thompson RM6836 | IA1_RS01610 | |||
| NCTC4840_03667 | 1,566 | S. Poona NCTC4840 | 3 | ADP-ribosyltransferase/PAAR-RhsA-Tox-ART-HYD1 | NCTC4840_03666 | No/No |