TABLE 4.

Natural products regulate glycolysis via multiple signaling pathways in liver cancer.

Name	Origin	Regulatory mechanism	Dose	Cell line/Experiment	References
Quercetin	Vegetables and fruits	AKT, mTOR	12.5,25,50 μM and 50 mg/kg	SMMG-7721, BEL-7402 cells and BALB/c nude mice	Wu et al. (2019a)
Deoxyelephantopin	Elephantopus scaber L	PI3K, Akt, mTOR	0.625,1.25,2.5,5,10,20,40 and 80 µM	HepG2 cells	(吴红雁 et al., 2023)
Rhizoma Paridis Saponins	Rhizoma Paridis	PI3K, Akt, mTOR	80 mg/kg	Kunming mice	Yao et al. (2018)
Chlorogenic acid	Plants	PI3K, AKT	25,50 and 100 μg/mL	HepG2 cells	Chen et al. (2019)
Prunella vulgaris total flavonoids	Prunella vulgaris L	Bcl-2, Bax	50,100,200,400 and 800 μg/μL	SMMG7721 cells	(宋亚刚 et al., 2020)
Echinacoside	Cistanche salsa	β-catenin	1,2,5,10 and 20 μg/mL	HepG2 and Huh7 cells and clinical samples	Wang et al. (2022b)
Morusin	Morus alba	AMPK, p-mTOR	2.5,5,10,20 and 40 μM	Huh7 and Hep3B cells	Cho et al. (2021)
Rosemary extract	Rosmarinus officinalis L	AMPK	2,10 and 50 μg/mL	HepG2 cells	Tu et al. (2013)
Cryptotanshinone	S. miltiorrhiza Bunge	AMPK	5,10,15,20,25 μM and 2.5 mg/kg	H22, Hepa1-6 cells and C57BL/6J mice	Jiang et al. (2022)