TABLE 5.

Natural products regulate glycolysis via oncogenes in liver cancer.

Name	Origin	Regulatory mechanism	Dose	Cell line/Experiment	References
Morusin	Morus alba	c-MYC	2.5,5,10,20 and 40 μM	Huh7 and Hep3B cells	Cho et al. (2021)
Deoxyelephantopin	Elephantopus scaber L	HIF-1α	0.625,1.25,2.5,5,10,20,40 and 80 µM	HepG2 cells	(吴红雁 et al., 2023)
α-tomatine	Tomato	HIF-1α	0.5,1,15,2 and 2.5 µM	HuH-7 cells	(何志龙 et al., 2022)
Triptolide	Tripterygium wilfordii Hook f	HIF-1α	10,40,60 and 100 nM	SMMC-7721 cells	(李恬 et al., 2020)
Apigenin	Vegetables and fruits	HIF-1α	20,40,80 μM and 400 mg/kg	HepG2 cells and athymic nude mice	(张睿 et al., 2020)
Curcumin	Curcuma longa L	HIF-1α	1,2,5,10 μM	HepG2 and HuT78 cells	Soni et al. (2020)
Genistein	Soybeans	HIF-1α	20,40,60,80,100,140 µM and 20,40,80 mg/kg	HCC-LM3, SMMC-7721, Hep3B, Bel-7402, Huh-7 cells and athymic BALB/c nu/nu mice	Li et al. (2017b)
Proanthocyanidin B2	Vegetables and fruits	HIF-1α	10,20,40,60,80,100,120 and 140 μM	HCC-LM3, SMMC-7721, Bel-7402, Huh-7 and HepG2 cells	Feng et al. (2019)
Ginsenoside CK	Panax ginseng C. A. Meyer	HIF-1α	20,40,60 μM	Bel-7404 cells	(苏杰琳 et al., 2021)
Prunella vulgaris total flavonoids	Prunella vulgaris L	ROS	50,100,200,400 and 800 μg/μL	SMMG7721 cells	(宋亚刚 et al., 2020)