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. 2023 Aug 17;14:1219209. doi: 10.3389/fimmu.2023.1219209

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Copyright © 2023 Feng, Deng, Huang, Liu, Ruan, Wang and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The connection between CSS model and cell infiltration characteristics in TME, as well as chemotherapy response. (A, B) The waterfall plot of tumor somatic mutation of high CSS score group (A) and low CSS score group (B). (C) The comparison of the abundance of immune cells infiltration in high and low CSS score groups by ssGSEA (*p< 0.05, **p< 0.01, ***p< 0.001, ****p< 0.0001; ns, no significance). (D–G) The differences in half-maximal inhibitory concentration (IC50) of chemotherapy drugs between high and low CSS score groups in the training set. Cisplatin (D), Gemcitabine (E), Mitomycin C (F), Methotrexate (G). (H–K) Linear regression analysis for chemotherapy drugs sensitivity and CSS score. Cisplatin (H), Gemcitabine (I), Mitomycin C (J), Methotrexate (K).