Table 4.
Registered clinical studies assessing response to meningococcal serotype B vaccines against gonorrhea, found at ClinicalTrials.gov.
| Title of Study | ClinicalTrials.gov ID | Sponsor | Location | Study Start | Study Completion | Description |
|---|---|---|---|---|---|---|
| Gonococcal vaccine study in key populations in Kenya (BexKPK) | NCT04297436 | University of Oxford | Kenya | 2021 | 2022 | Assess humoral and T-cell responses elicited by 4CMenB against N. gonorrhoeae |
| Safety and efficacy study of meningococcal group B vaccine rMenB+OMV NZ (Bexsero) to prevent gonococcal infection | NCT04350138 | National Institute of Allergy and Infectious Diseases | United States; Thailand | 2020 | 2023 | Phase 2 randomized, observer-blind, placebo-controlled, multi-site trial of 4CMenB |
| Efficacy study of 4CMenB (Bexsero) to prevent gonorrhoea (GoGoVax) | NCT04415424 | Kirby Institute | Australia | 2021 | 2025 | Phase 3, double-blinded, randomized placebo-controlled, multi-centred trial evaluating the efficacy of 4CMenB in prevention of N. gonorrhoeae infection |
| Mucosal immunity against Neisseria gonorrhoeae after 4CMenB vaccination | NCT04722003 | National Institute of Allergy and Infectious Diseases | United States | 2021 | 2023 | Phase 2 mechanistic clinical trial to assess the systemic and mucosal immunogenicity of 4CMenB against N. gonorrhoeae |
| Study to assess gonorrhea immune responses induced by a N. meningitidis vaccine | NCT04094883 | University of North Carolina, Chapel Hil | United States | 2019 | 2020 | Test of whether 4CMenB induces immune responses to N. gonorrhoeae |
| A study to learn about how Trumenba vaccine shots work against gonorrhea infection in teenagers and young adults in the United States | NCT05873751 | Pfizer | United States | 2023 | 2023 | Retrospective cohort study of subjects who have received the meningococcal serotype B vaccine Trumenba |
| Efficacy of immunizion with 4CMenB in preventing experimental urethral infection with Neisseria gonorrhoeae | NCT05294588 | University of North Carolina, Chapel Hill | United States | 2022 | 2028 | Double-blind, randomized controlled trial to test the efficacy of 4CMenB in preventing N. gonorrhoeae infection in a controlled human challenge model |
| Immunization for adolescents against serious communicable diseases (B part of it NT) | NCT04398849 | University of Adelaide | Australia | 2021 | 2024 | Observe effectiveness of 4CMenB against gonococcal carriage |
| Efficacy trial on meningococcal B vaccine for preventing gonorrhea infections | NCT05766904 | Chinese University of Hong Kong | Hong Kong | 2023 | 2025 | Randomized double-blind placebo-controlled trial testing the efficacy of 4CMen B on incidence of gonorrhea in men-who-have-sex-with-men |