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. 2023 Aug 17;14:1199513. doi: 10.3389/fimmu.2023.1199513

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Copyright © 2023 Flies, Langermann, Jensen, Karsdal and Willumsen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ECM receptors that may regulate tumor immunity in cancers. ECM receptors and their primary ligands (collagens, fibronectin, hyaluronic acid (HA), proteoglycans). The ECM stimulates or inhibits cellular activity through these receptors in response to, and dependent on, an injured, remodeled, or dysregulated ECM composition. LAIR-1, Leukocyte-Associated Immunoglobulin-like Receptor-1. LAIR-2, Leukocyte-Associated Immunoglobulin-like Receptor-2. OSCAR, Osteoclast-associated receptor. DDR-1/2, Discoidin Domain Receptors 1 and 2. LILRB4, Leukocyte immunoglobulin-like receptor subfamily B member 4 (a.k.a. ILT3). CD44, Cluster of differentiation 44. TLR, Toll-Like Receptor. Figure created with BioRender.com.