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Tumor ECM as a T cell barrier and regulator of T cell activity. Aberrant collagen expression may both exclude immune cells from infiltrating the TME, and at the same time prevent T cells from becoming activated and developing into cytotoxic effector T cells. LAIR-1 as an example plays both a role in cellular adhesion to the ECM, and at the same time delivers signals to instruct immune cells to remain in a sub-optimal state of activation. Figure created with BioRender.com.
