Table 5.

Dosage of important antibiotics used in acute bacterial meningitis in adults

Antibiotic	Dosage per day
Penicillin G	6 × 5 Mio IE
Ampicillin	6 × 2 g
Cefotaxim	4 (bis 6) x 2 g
Ceftazidime	3 × 2 g
Ceftriaxone	1 × 4 oder 2 × 2 g
Meropenem	3 × 2 g
Fosfomycin	3 × 5 g2
Rifampicin	1 × 600 mg
Vancomycin	2 × 1 g1
Linezolid	2 × 600 mg
Gentamicin	1 × 240–360 mg3
Metronidazole	3 × 500 mg

¹Determination of serum levels required. Cave: Dexamethasone might impair the penetration of vancomycin into the CSF [44]. ²Possibly, a fosfomycin-dosage of 3 × 8 g/d is needed to treat ventriculitis [45]. ³The daily gentamicin-dosis is 3–6 mg/kg KG. Determination of serum levels required