Supplementary Figure S1.

Intravenous challenge study schema. Study design, including relative timing of vehicle injection, lenacapavir (LEN) injection, initiation (blue downward arrow) and discontinuation (blue upward arrow) of daily oral TDF/FTC/DTG administration, and intravenous stHIV-A19 challenge. Following stHIV-A19 challenge, each group was monitored for the indicated duration. Animals in the vehicle control and TDF/FTC/DTG control groups were followed for a shorter duration than the LEN groups following stHIV-A19 challenge because they were repurposed for other studies to conserve animal resources. I.U., infectious units.