Fig. 3.

Plasma viral loads following stHIV-A19 challenge. Longitudinal plasma viral loads for (a) vehicle control, (b) TDF/FTC/DTG control PrEP, and (c) LEN PrEP group animals prior to and following intravenous stHIV-A19 challenge. The timing of vehicle, LEN, and stHIV-A19 injections are indicated by arrows. The grey shaded region in (b) indicates a 7-day period of daily TDF/FTC/DTG administration, beginning three days prior to stHIV-A19 challenge. Horizontal dashed lines indicate the assay quantification limit (2.8 vRNA copies/ml plasma). Plot symbols below the quantification limit represent specimens in which no viral RNA was detected.