Table 1:

List of available Solvers in GillesPy2 as of version 1.7.0.

Algorithm	Implementation / Reference	Class Name	Language	Advanced Features
SSA	Direct Method / Gillespie, 1977	NumPySSASolver	Python
SSA	Direct Method / Gillespie, 1977	SSACSolver	C++
Tau-Leaping	Cao et al., 2006	TauLeapingSolver	Python
Tau-Leaping	Cao et al., 2006	TauLeapingCSolver	C++
ODE	LSODA∗ / Petzold, 1983	ODESolver	Python∗
ODE	LSODA∗ / Petzold, 1983	ODECSolver	C++∗
CLE	Euler-Maruyama / McCauley, 2013	CLESolver	Python
Tau-Hybrid	see Section 3	TauHybridSolver	Python	Event, RateRule, AssignmentRule, FunctionDefinition
Tau-Hybrid	see Section 3	TauHybridCSolver	C++	Event, RateRule

^∗The ODE solvers are wrappers to SciPy (Virtanen et al., 2020) (Python) and SUNDIALS (Hindmarsh et al., 2005) (C++) solvers. The ODE solvers use LSODA by default but other integrators can be chosen.