Fig 5.

Exogenous IFN treatment fails to improve viral clearance in genetically OB mice. (A) IFN expression in lungs of treated or untreated WT and OB mice. (B and C) WT and IFNAR^−/− mice treated with OSV or vehicle (PBS) and inoculated with CA/09. Lung viral loads quantified at days 3 and 7 p.i. (D) WT and OB mice treated with OSV, recombinant IFNα or vehicle (PBS) and inoculated with CA/09. Lung viral loads measured at day 6 p.i. Data represented as means ± SEM and analyzed via ordinary one-way ANOVA with Tukey’s multiple comparisons with α = 0.05. OSV = oseltamivir phosphate.