TABLE 2.
Percentage of detected minor variants in OB and WT mice treated with oseltamivir
| Segment | SNV | Mutation | Obesea | Wild-typeb | Natural prevalencec | ||
|---|---|---|---|---|---|---|---|
| OSV | PBS | OSV | PBS | ||||
| HA | T28C | I10T | 6.1 | 80.8 | |||
| T333A | D111E | 30.6 | >0.1 | ||||
| A399G | I133M | 5.9 | 0.7 | ||||
| C432A | D144E | 11.0 | 36.4 | >0.1 | |||
| A515G | E172G | 5.3 | 8.1 | 28.1 | 13.4 | 78.2 | |
| A517G | N173D | 7.1 | 0.3 | ||||
| C598T | P200S | 5.0 | 67.6 | ||||
| T853A | S285T | 5.9 | >0.1 | ||||
| T935C | I312T | 22.3 | >0.1 | ||||
| A957T | K319N | 5.4 | >0.1 | ||||
| G1168A | D390N | 7.8 | 13.7 | ||||
| T1187C | V396A | 8.2 | >0.1 | ||||
| C1193T | S398F | 31.8 | >0.1 | ||||
| G1228A | V410I | 16.4 | >0.1 | ||||
| T1298A | L433Q | 6.0 | >0.1 | ||||
| C1421T | A474V | 19.1 | >0.1 | ||||
| A1573G | T525A | 10.0 | >0.1 | ||||
| A1579G | I527V | 6.7 | 13.7 | ||||
| T1610C | V537A | 5.8 | 4.8 | ||||
| T1654C | F552L | 43.6 | >0.1 | ||||
| G1688A | R563K | 19.2 | 0.3 | ||||
| NA | A129T | Q43H | 11.6 | >0.1 | |||
| A149G | N50S | 5.0 | 0.1 | ||||
| C377T | P126L | 7.5 | 0.1 | ||||
| T614C | V205A | 7.5 | >0.1 | ||||
| G700A | V234I | 5.4 | 0.4 | ||||
| G1139A | W380 | 9.7 | >0.1 | ||||
| G1197A | W399 | 6.7 | >0.1 | ||||
a
Shannon’s entropy (H) of HA of nontreated versus treated OB mice: 2.30 to 3.27, NA: 0.60 to 0.36.
b
Shannon’s entropy (H) of HA in nontreated versus treated WT mice: 1.98 vs 1.25, NA: 0.22 to 0.77.
c
Prevalence of minor variants in human surveillance samples on the Influenza Research Database.