Table 1.

Associations of 5mC, 5hmC, 5fC, and 5caC with the clinicopathological parameters of colon carcinomas (*P < .05).

Parameters	Sample			Levels of 5mC		Levels of 5hmC		Levels of 5fC		Levels of 5caC
Groups	Total tissues (n = 100)	Colon cancer (n = 100)	Adjacent non-tumor (n = 60)	Moderate positive (n = 72)	Strong positive (n = 18)	Moderate positive (n = 81)	Strong positive (n = 15)	Moderate positive (n = 77)	Strong positive (n = 17)	Moderate positive (n = 47)	Strong positive (n = 11)
Age (yr)	62.4 ± 11.64	62.4 ± 11.64	62.15 ± 12.46	63.61 ± 11.26	58.94 ± 11.54	61.84 ± 12.09	65.60 ± 8.22	61.9 ± 12.29	63.94 ± 8.98	61.45 ± 12.47	64.73 ± 12.63
			P = .898		P = .979		P = .043*		P = .075		P = .687
Gender
Male (%)	58	58	58.3	59.7	55.6	56.5	66.7	57.1	58.8	59.6	54.5
Female (%)	42	42	41.7	40.3	44.4	43.5	33.3	42.9	41.2	40.4	45.5
			P = .967		P = .748		P = .461		P = .899		P = .760
Site
Right colon (%)	48	50	45	44.4	61.1	48.2	46.7	44.2	58.8	40.4	45.5
Left colon (%)	24	24	26.7	25	16.7	24,7	20	28.6	5.9	27.7	27.3
Rectosigmoid colon (%)	28	26	28.3	30.6	22.2	27.1	33.3	27.3	35.3	31.9	27.3
			P = .828		P = .447		P = .859		P = .088		P = .943
Gross pattern
Lumpy (%)	22	21	16.7	20.8	27.8	23.5	13.3	19.5	41.2	14.9	36.4
Ulcerous (%)	61	61	66.7	61.1	50	58.8	73.3	66.2	35.5	70.2	54.5
Invasive (%)	17	18	16.7	18.1	22.2	17.6	13.3	14.3	23.5	14.9	9.1
			P = .744		P = .688		P = .535		P = .057		P = .258
Stage
II (%)	57	55	55	54.2	55.6	54.1	73.3	58.4	64.7	57.4	63.6
III (%)	38	40	40	41.7	33.3	40	26.7	37.7	29.4	38.3	27.3
IV (%)	5	5	5	4.2	11.1	5.9	0	3.9	5.9	4.3	9.1
			P = 1.000		P = .471		P = .218		P = .785		P = .684
Microsatellite instability (MSI) (%)	31	31	25	26.4	38.9	30.6	33.3	32.5	23.5	25.5	27.3
			P = .417		P = .295		P = .832		P = .470		P = .906

5caC = 5-carboxylcytosine, 5fC = 5-formylcytosine, 5hmC = 5-hydroxymethylcytosine, 5mC = 5-methylcytosine.