Table 2.

Interaction assessment between VKORC1 and CYP4F2 and variables of interest.

Variable 1	Variable 2	OR (95%CI)	P value
Smoking	CYP4F2	3.913 (2.050; 7.468)	<.001
Smoking	VKORC1	2.802 (1.645; 4.773)	<.001
Smoking	CYP4F2 or VKORC1	3.114 (1.886; 5.141)	<.001
History of MI	CYP4F2	4.116 (0.865; 19.580)	.07
History of MI	VKORC1	2.842 (0.893; 9.051)	.07
History of MI	CYP4F2 or VKORC1	2.919 (1.035; 8.232)	.043
AH	CYP4F2	1.731 (1.189; 2.521)	.004
AH	VKORC1	1.781 (1.247; 2.543)	.001
AH	CYP4F2 or VKORC1	1.753 (1.228; 2.502)	.002
LDL-C > 77 mg/dL	CYP4F2	1.334 (0.935–1.903)	.1
LDL-C > 77 mg/dL	VKORC1	1.093 (0.769–1.554)	.6
LDL-C > 77 mg/dL	CYP4F2 or VKORC1	1.162 (0.801; 1.688)	.4
Carotid plaque	CYP4F2	2.176 (1.428; 3.314)	<.001
Carotid plaque	VKORC1	2.427 (1.661; 3.546)	<.001
Carotid plaque	CYP4F2 or VKORC1	2.468 (1.710; 3.564)	<.001

AH = arterial hypertension, CI = confidence intervals, LDL-C = low-density lipoprotein cholesterol, MI = myocardial infarction.