Table 2.

MR result of gut microbiota on CRP.

Exposure	Methods	Number of SNPs	Beta	Se	Pval	Cochran’s Q statistic (P-value)	Egger intercept(P-value)	F
CRP(Outcome)
family Coriobacteriaceae	IVW-FE	12	-0.502	0.252	4.59E-02	0.642	0.582	19.388
class Coriobacteriia	IVW-RE	12	-0.502	0.252	4.59E-02	0.642	0.582	19.388
order Coriobacteriales	MR Egger	12	-1.304	1.430	3.83E-01	0.642	0.582	19.388
	WM	12	-0.492	0.335	1.42E-01	0.642	0.582	19.388
class Mollicutes	IVW-FE	6	0.736	0.292	1.17E-02	0.878	0.760	18.688
phylum Tenericutes	IVW-RE	6	0.736	0.292	1.17E-02	0.878	0.760	18.688
	MR Egger	6	0.408	1.043	7.16E-01	0.878	0.760	18.688
	WM	6	0.819	0.370	2.68E-02	0.878	0.760	18.688
genus Dialister	IVW-FE	9	0.585	0.238	1.41E-02	0.267	0.463	18.297
	IVW-RE	9	0.585	0.266	2.80E-02	0.267	0.463	18.297
	MR Egger	9	1.523	1.238	2.58E-01	0.267	0.463	18.297
	WM	9	0.410	0.335	2.22E-01	0.267	0.463	18.297
genus Gordonibacter	IVW-FE	9	0.293	0.136	3.10E-02	0.927	0.822	18.667
	IVW-RE	9	0.293	0.136	3.10E-02	0.927	0.822	18.667
	MR Egger	9	0.162	0.574	7.86E-01	0.927	0.822	18.667
	WM	9	0.188	0.178	2.89E-01	0.927	0.822	18.667

IVW-FE, Inverse variance weighted-fixed model; IVW-RE, Inverse variance weighted-random model; WM, weight median; CRP, C reactive protein; F is the value of F statistics to examine the weak instrument bias.

Bold means that the p-value is less than 0.05.