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Two-step Mendelian randomization.
| Exposure | Mediation | Total effect (Beta) | A (Beta) | B (Beta) | Indirect effect (Beta) | Mediation effect/ Total effect |
|---|---|---|---|---|---|---|
| Sepsis (under 75)(Outcome) | ||||||
| phylum tenericutes/ class Mollicutes | CRP | 0.102 | 0.736 | 0.044 | 0.033 | 32.02% |
| Sepsis(Outcome) | ||||||
| genus Gordonibacter | CRP | 0.045 | 0.293 | 0.045 | 1.32% | 31.53% |
A, the effect of Exposure on Mediation; B, the effect of Mediation on Outcome is independent of the effect of the exposure.
