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. 2023 Aug 24;19(8):e1010888. doi: 10.1371/journal.pgen.1010888

Fig 1. Volcano plots of differential gene expression at 6h Mtb infection by PMN from HITTIN and HIT.

Fig 1

Volcano plot for transcriptional responses to Mtb challenge for neutrophils from HITTIN (PMNHITTIN) and HIT (PMNHIT) participants at 6h (A-C) post Mtb infection. The y-axis shows the negative log10 unadjusted P value and the x-axis the log2 fold change (FC). The vertical dashed lines represent log2FC thresholds of -0.2 and 0.2. Each gene is represented by a dot. Genes which are downregulated or upregulated as determined by the FDR ≤ 5% are shown in blue and red, respectively. Genes with non-significant expression changes and below the log 2FC threshold are shown in grey. Differentially expressed genes at 6h post-infection compared to 6h uninfected PMN from HITTIN (PMNHITTIN) (A) and HIT participants (PMNHIT) (B). Significant differentially triggered genes between PMNHITTIN and PMNHIT at 6h post infection (C).