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. 2023 Aug 21;17(8):e0011552. doi: 10.1371/journal.pntd.0011552

Fig 1. KLRK1 is expressed in lesions and is correlated with cytolytic genes.

Fig 1

RNAseq analysis from 7 healthy skin (HS) and 21 lesions from L. braziliensis-infected patients (CL). (A) Gene expression of KLRK1, which encodes NKG2D. (B) Correlation shows KLRK1 expression compared to GZMB, GNLY, and PRF1. (C) Correlation shows KLRK1 expression compared to MCP counter abundance scores for CD8 T cell and CTL score. Gene expression is represented as counts per million (CPM) in the log2 scale. (D and E) Cells isolated from lesions or PBMC obtained from HS and L. braziliensis patients were stained for flow cytometry directly ex vivo and depicted are representative flow cytometry plots (D) and scatter plots (E) of NKG2D expression in CD8 T cells. Data were obtained from 5 HS and 9 L. braziliensis patients. HS, healthy subjects; CL, cutaneous leishmaniasis; PBMC, peripheral blood mononuclear cells. *p<0.05. *p < 0.05, **p ≤ 0.01, ***p ≤ 0.001, ****p < .0001.