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. 2023 Aug 21;17(8):e0011552. doi: 10.1371/journal.pntd.0011552

Fig 3. IL-15 induces NKG2D expression on CD8 T cells from L. braziliensis-infected patients.

Fig 3

RNAseq analysis from 7 healthy skin (HS) and lesions from 21 L. braziliensis-infected patients (CL). (A) Gene expression of IL15, IL15RA, IL2RG, and IL2RG in the skin of HS and lesions from L. braziliensis-infected patients. (B) Correlation between KLRK1 expression and IL15, IL15RA, IL2RB, and IL2RG expression in the lesions. Gene expression is represented as counts per million (CPM) in the log2 scale. (C–F) PBMCs from L. braziliensis-infected patients and healthy subjects were cultured with IL-15 for 18h and stained for flow cytometry. Dot plots (C and E) and graph bars represent (D and F) NKG2D expression by CD8 T cells after IL-15 stimulation. Data were obtained from 5 healthy subjects and 7 L. braziliensis-infected patients. HS, healthy skin; PBMC, peripheral blood mononuclear cells. **p ≤ 0.01, ***p ≤ 0.001, ****p < .0001.