Figure 1:

The dynamics of human follicular development and reserve during fetal development and in adult. Oocyte and follicle reserve decline in the ovary during aging. Follicular quantity reaches maximum at 16/20 weeks of fetal development [18, 19]. Approximately one million viable follicles remain at birth, the mechanism of primordial follicles loss remains to be fully determined [20]. At the time of menarche, women have 300,000 to 400,000 follicles, which are recruited cyclically until menopause (approximately 1000 follicles) [21]. yr, year.