Figure 3:
The effect of composition, size and surface of iron-based nanoparticles on the macrophage polarization. A. (i) Schematic diagram of the macrophage polarization effects of Fe2O3@SiO2 and Fe3O4@SiO2 with different the ratio (R) of intracellular iron accumulation. (ii) Antitumor properties of IONPs with different components in the melanoma tumor model. Reproduced with permission [68]. Copyright © 2019 American Chemical Society. B. TEM images (i, ii) and schematic diagram (iii) of nanoparticles with a polymer coating and surface PEGylation. (i. PMA/IO NPs; ii. PMA/IO-PEG NPs). (iv) Gene expression in RAW264.7 cells after IONPs treatment for 24 h. Reproduced with permission [63]. Copyright 2019, RSC Pub. C. (i) Characteristic of three differently charged SPION. (ii) Immunohistochemical staining of different treatment groups. The green area reflects the expression of CD206, CD11b and CD80. Reproduced with permission [90]. Copyright © 2020 Zhang, Cao, Liang, Tan, Luo, Xu and Saw.