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. 2023 Jan 16;2(6):555–569. doi: 10.1515/mr-2022-0033

Table 4:

Advantages and disadvantages of different therapeutic antibodies.

Name Advantage Disadvantage
Monoclonal antibody
  • 1.

    Easy to prepare with high purity

  • 2.

    Well-defined mechanism of action
  • 1.

    Drug resistance

  • 2.

    “On-target off-tumor” side-effect
Antibody-drug conjugate
  • 1.

    Efficient tumor cell killing

  • 2.

    Not easy to resistance

 “On-target off-tumor” side-effect
Bispecific antibody
  • 1.

    High efficiency

  • 2.

    Activate host immune response

 “On-target off-tumor” side-effect
Antibody fusion proteins
  • 1.

    High efficiency

  • 2.

    Activate host immune response

 Undefined mechanism of action