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. 2023 Sep 1;133(17):e167693. doi: 10.1172/JCI167693

Figure 5. The nitrate-mediated protective effect of RBCs is dependent on sGC and transport by MRP.

Figure 5

Percentage recovery of LVDP during reperfusion (A) following administration of RBCs from vehicle-treated and nitrate-treated mice under control conditions (n = 7 and 9, respectively) and following incubation with the sGC inhibitor ODQ (n = 5) or (B) following administration of RBCs from vehicle-treated and nitrate-treated control WT mice (n = 7 and 9, respectively) and from sGC KO mice (n = 15 and n = 8, respectively). (C) Recovery of LVDP following administration of RBCs from vehicle-treated and nitrate-treated WT mice to hearts from WT mice (n = 9 and 6, respectively), and nitrate-treated WT mice to hearts from sGC-KO mice (n = 5) and (D) vehicle-treated and nitrate-treated mice (n = 7 and 9, respectively) following incubation with the MRP-inhibitor MK571 (n = 4). The recovery of LVDP is expressed as percentage of the preischemic level. Data are presented as mean ± SD. ***P < 0.001 denotes significant differences to the vehicle group by 2-way ANOVA followed by Tukey’s multiple comparison test.