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. 2023 Sep 1;133(17):e167693. doi: 10.1172/JCI167693

Figure 6. RBCs mediate cardioprotection via activation of cardiac PKG.

Figure 6

(A) Percentage recovery of LVDP during reperfusion and (B) infarct size following administration of supernatant collected from hypoxic RBCs and administration of supernatant following perfusion of the heart with the PKG inhibitor KT5823 (1 μM; KT5823perfusion; n = 6). (C) Recovery of LVDP and (D) infarct size following administration of supernatant collected from hypoxic RBCs and vehicle (n = 8) or with the PKG inhibitor Rp-8-Br-cGMPS (n = 5). Data are presented as mean ± SD. **P < 0.01 and *** P < 0.001 denote significant differences between groups or to the vehicle group by 2-way ANOVA followed by Tukey’s multiple comparison test in A and C and unpaired t test in B and D.