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. 2023 Sep 1;133(17):e167693. doi: 10.1172/JCI167693

Figure 9. Dietary nitrate in humans enables RBCs to mediate cardioprotection.

Figure 9

RBCs collected from 2 groups of subjects randomized to high nitrate intake in the form of nitrate pills or nitrate-rich vegetables and 1 group subjected to low dietary intake of nitrate were given to isolated rat hearts subjected to ischemia reperfusion. The RBCs were investigated (A) at baseline before randomization (n = 14–16 in each group), (B) at end of treatment (n = 14–16), and (C) at end of treatment following incubation of the RBCs with the sGC inhibitor ODQ (n = 11–13). Data show percentage recovery of LVDP during reperfusion and are presented as mean ± SD. ***P < 0.001 denotes significant differences to the low nitrate vegetables+placebo pill group by 2-way ANOVA followed by Tukey’s multiple comparison test.