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. 2023 Sep 1;133(17):e171554. doi: 10.1172/JCI171554

Figure 6. Clonality of the latent reservoir of PWH on very long-term ART.

Figure 6

(A) Clonality of QVOA isolates. Clonality was estimated as the fraction of env sequences that exactly matched another env sequence from an independent isolate obtained in the same QVOA. Clonality of outgrowth sequences for participants with over 10 positive QVOA outgrowth wells was compared between PWH on very long-term ART (R01, R02, R03, R10, R16, R18, and R21; orange symbols) and PWH on ART for an average of 9.0 years (red symbols) from 5 previous studies (45–47, 57, 75). In those 5 studies, clonality measurements included sequences obtained only from the first time point using the same QVOA methods with only 1 round of stimulation and from participants who experienced no analytical treatment interruptions and had no additional treatments besides ART. The mean values (thick line) and statistical significance (Student’s t test) are indicated. (B) Difference in clonality between QVOA isolates and proviral env sequences. Clonality of outgrowth sequences for very long-term ART participants with over 10 positive QVOA outgrowth wells (R01, R03, R10, R16, R18, and R21) was compared with the clonality of proviral sequences obtained from resting CD4+ T (rCD4) cells of the same participant. Statistical significance (Student’s paired t test) is indicated.