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. 2023 Aug 17;13:1240008. doi: 10.3389/fonc.2023.1240008

Table 2.

Characteristics of studies included in this meta-analysis.

Study, year Country Duration Sample size Tumor type Study design Treatment Survival outcome Cut-off NOS
Asakura et al., 2022 (23) Japan 2000-2019 169 ECC Retrospective Surgery OS 3 6
Cui et al., 2018 (22) China 2012-2017 73 HCCA Retrospective PTBS+ 125I OS 2 5
Mito et al., 2023 (21) Japan 2006-2020 224 BTC Retrospective Surgery OS, RFS, DSS 4 6
Miyata et al., 2017 (20) Japan 2002-2016 71 ICC Retrospective Surgery OS, RFS 2 7
Shimizu et al., 2022 (19) Japan 2002-2018 91 AVC Retrospective Surgery OS 2 7
Sun et al., 2021 (18) China 2002-2017 371 BTC Retrospective Surgery OS 2 6
Terasaki et al., 2022 (17) Japan 2002-2016 149 DCC Retrospective Surgery OS 3 6
Wang et al., 2021 (16) China 2010-2019 94 HCCA Retrospective Surgery OS, RFS 3 7
Zheng et al., 2020 (15) China 2012-2018 167 ICC Retrospective Surgery OS, RFS 3 7

ECC, extrahepatic cholangiocarcinoma; OS, overall survival; HCCA, hilar cholangiocarcinoma; PTBS+ 125I, percutaneous transhepatic biliary stenting combined with 125I seed intracavitary irradiation; BTC, biliary tract cancer; RFS, relapse-free survival/recurrence-free survival; DSS, disease-specific survival; ICC, intrahepatic cholangiocarcinoma; AVC, ampulla of Vater cancer; DCC, distal cholangiocarcinoma.